Cayuse 424

10 Quick Steps to Building a Proposal in Cayuse 424

Step 1: Log in to Cayuse 424.

  1. Login to Cayuse 424 from the CUW portal using your username and password.
  2. Click on the “Resources” tab or the “Faculty” tab.
  3. Scroll down to locate the Cayuse 424 login link.

Step 2: Set up or update your Professional Profile.

Professional Profiles have been set up under the People tab for all current PIs. It is your responsibility to keep your profile updated. Only you have access to change your profile information, unless you grant permission to others. You may upload and store multiple biosketches in your Professional Profile. Any PI without a Professional Profile must create one prior to starting a grant application. Key persons and other significant contributors must have a Professional Profile as well.

Step 3: Find an Opportunity.

The Opportunities tab displays a list of federal funding Opportunities that have been downloaded into Cayuse 424 from To retrieve an Opportunity from, you must know the Opportunity Number or CFDA Number. Once you have one of these numbers:

  1. On the Opportunities tab, click Retrieve Opportunities.
  2. Enter the Opportunity Number or CFDA Number.
  3. Click Retrieve Opportunities.

Click the Opportunity Details icon to the left of the Opportunity Number for more information about the Opportunity. Click the Create Proposal icon to create a proposal using that Opportunity.

Step 4: Create your proposal.
There are two ways to create a proposal: (a) On the Opportunities tab, click the Create Proposal icon to the left of an Opportunity; or (b) On the Proposals tab, click Create Proposal at the top of the screen.

Per OSP procedure, your proposal must be named as follows: [PI Last Name]-[Mechanism]-[Sponsor]-[Due Date]. For example: Smith-R01-NIH-11/15/11

Step 5: Grant proposal permissions to the appropriate people.

The proposal creator is automatically granted full permissions to the proposal. The proposal creator is the only user that can initially grant proposal permissions to other users. As the proposal creator, you must grant the appropriate permissions to other users who require access to the proposal, including other principal investigators and department administrators. Please remember to provide access to the Office of Sponsored Programs.

Step 6: Complete the forms and attach necessary documents.

All forms in the Opportunity are located in the navigation bar on the left side of the screen. Mandatory forms are automatically checked and cannot be unchecked. Optional forms may be checked if you wish to submit those forms to the sponsor.

Step 7: Build the budget.

Check your proposal solicitation for specific budgetary requirements (i.e., whether to build a detailed budget, modular budget, or subaward budget). You may specify up to ten (10) budget periods. Cayuse 424 performs budget calculations after you enter salary, personnel effort, fringe benefits, and other required amounts. Cayuse 424 can also perform cost replication and escalation for all budget categories.

Step 8: Check for errors and warnings in the proposal.

Cayuse 424 keeps a running list of errors and warnings. Errors reflect problems that will impose a hard-stop rejection at or the funding agency. Errors must be corrected prior to submitting the proposal. Warnings are not critical, but they may cause a proposal to be rejected from the funding agency. Items labeled “Info” are tips and recommendations from Cayuse; they will not prevent the proposal from being submitted.

Click the Error / Warning / Info button at the bottom of the proposal to display the validations panel. Click the hyperlink in the validation message to be taken to the field in question. Cayuse 424 will highlight the field that contains the error or warning. The number of Error / Warning / Info messages decreases as you correct the issues.

Step 9: Notify the OSP that your proposal is ready for review.

After you have completed the required SF424 forms, uploaded documents in PDF format, and fixed any errors or warnings, please notify the Office of Sponsored Programs that your proposal is ready for review.

The Office of Sponsored Programs will submit your proposal.

Step 10: Track your proposal after it has been submitted to

When the proposal is submitted, a tracking number is recorded in the Proposal Submission History. Click the Submission icon to view the tracking number, date and time of receipt, and submitter.

The Office of Sponsored Programs receives a series of emails from indicating receipt and acceptance or rejection of the application. The PI receives an email regarding the status of the proposal. Sometimes this email requests the PI to review and approve the proposal on the funding agency website.

Questions? Please contact the Office of Sponsored Programs:

Julie Dresen – – (262) 243-2794
Cathy Melan – – (262) 243-2030